Saturday, September 11, 2010

Seven Heart Friendly Foods

When it comes to eating, a little bit of everything is the key. Our body needs all foods in moderation. Some help cure bowel problems, some help control diabetes and some keep eye problems at bay. Here are seven foods you should include in your diet to have a healthy heart.

Apples
Apples are a good source of vitamins and minerals like iron, phosphorus, potassium, calcium as well as vitamins A, B and C. These help in strengthening blood vessels. . They also have a low glycemic index, making it safe for diabetics to consume.

Garlic
Garlic contains aicin, a powerful antioxidant. Other than that, It helps lower the bad cholesterol. This means it prevents your arteries from getting clogged. So use this condiment in your curries, stir-fries and more.

Fish
Oily fish contains omega-3 fatty acids that help to maintain the integrity of blood vessels by keeping them healthy and elastic. These acids also improve our immune system and help in increasing the good cholesterol or HDL levels. It also reduces the chances of blood clots.
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Olive oil

Due to the mono-saturated fats present, olive oil helps in lowering the amount of bad cholesterol. It is also rich in antioxidants that increase the elasticity of arterial walls. This in turn prevents heart-related problems.

Wheat

Wheat is a very good source of fibre, vitamins and minerals. It helps in reducing the amount of bad cholesterol. Fibre binds with the cholesterol and helps in eliminating it from our body. Other sources of fibre are: oats, barely, bajra, ragi, jowar and other whole grains.

Dairy
Milk and milk products are a good source of fatty acids. They are also a good source of antioxidants and polyphenols. Polyphenols protect blood vessels and lower blood pressure, thus preventing cardiovascular diseases.

Greens
Green leafy vegetables like spinach and fenugreek are a good source of vitamin B-complex and niacin. These protect the blood vessels from clots and prevent hardening of arteries.
A healthy diet and moderate exercise will go a long way in maintaining a healthier heart and a happier you!

Thursday, September 9, 2010

Balance Disorders are Curable

Prevalence
It has been found that 5% of all patients going to the general practitioner and 10% of patients going to the ENT specialist or neurotologist suffer from balance disorders. Giddiness / vertigo / instability is one of the most common complaints heard in a doctor's chamber. All of them indicate a disorder of the balance system. Exact figures of prevalence of balance disorder in our country is not available, but the American National Institute of Health Statistics has reported that 42% of the nation's population presents to the doctor's clinic with vertigo / imbalance sometimes in their lives. According to the National Ambulatory medical Care Survey from1991, balance related problems (giddiness - instability) are among the 25 most common causes for which Americans visit the doctor. There is more than 5 million vertigo - instability related visits to the doctor every year in USA. Instability and unsteadiness are very common in old aged persons and the apprehension of falling or losing balance is a very common health concern in people above 65 years of age. The American National Institute of Health Statistics has reported that balance related falls account for 50% of accidental deaths in the population above 65 yrs. All these statistics show the high incidence of balance disorders in GPs practice.

Balance Disorders are Curable
Balance disorders are a very common medical problem but fortunately diseases of the balance system are very rarely life - threatening conditions and most of them are self - limiting. More than 90% of patients suffering from balance disorders are cured totally only by medication and some exercises. Rarely however, surgery is required, and in a very few, the disorder is of unknown origin (idiopathic) and refractory to treatment. It is very essential that the vertiginous patient gets proper medical treatment. General practitioners can very efficiently manage most cases of vertigo but specialized management by a neurotologist is occasionally required. Those patients who have associated features like ear problems e.g. deafness / tinnitus / fullness / aural discharge, headache, visual disturbances e.g. blurring of vision / diplopia and neurological problems like motor / sensory disturbances require referral to neurotologist. The other balance disorder patients who require referral are those in whom the giddiness or instability is persistent after 4 weeks or in whom the symptoms are progressively deteriorating with no signs of recovery. A neurotologist is a medical person who is specialized in the management of balance disorders. The patient usually requires some specialized investigations by which the neurotologist can identify and document the patient's disability and also establish the cause and localize the site of disorder in the balance system. After identifying the pathology, the neurotologist treats the patient according to the nature and site of disorder. Though most balance - disorders are benign, self limiting conditions, yet the medical practitioner should not take it lightly as sinister conditions like a tumour in the brain or a disabling condition like multiple sclerosis or even a cerebral stroke localised to the posterior part of the brain may present with vertigo / instabiliy only. Hence patients presenting with vertigo / instability should be very thoroughly investigated by a neurotologist if the patient does not recover within a maximum of 4 weeks time or if the patient has other concomitent symptoms enumerated.

Medical, Physical and Surgical Therapy
If the tests point to a unilateral peripheral vestibular disorder (which is the commonest finding), the vestibular rehabilitation exercises are the mainstay of treatment. However, some vestibular sedative drugs are prescribed along with not only to give symptomatic relief to the patient during this acute phase but also to increase the blood supply to the vestibular system ( mainly the inner ear and certain parts of the brain) because quite often these attacks of vertigo / instability is due to a phenomenon called vasospasm. Vertigon is very effective in these cases, as, it in addition to its vestibular sedative effect (which reduces the giddiness symptomatically) it also prevents vasospams in the brain and thereby ensures a proper supply of blood (which carries oxygen and glucose) to the inner ear and brain. Prochlorperazine and Dimenhydrinate are only strong vestibular sedatives and does not have the anti-vasoconstrictive effect of Vertigon. However, there are other drugs too like Betahist which increase the blood supply to the vestibular system by different mechanisms. In addition to drugs like- Vertigon, Prochlorperazine, or Betahist some other drugs, e.g. anti-emetics like Domperidone are also needed to take care of the vegetative symptoms of the patient like nausea, vomiting etc. which usually accompany vertigo. Antioxidents, Vitamines B1 / B6 / B12 and drugs for enhancing blood supply to the brain have a big role in the management of chronic vertigo. When one of the vestibular labyrinths in the ear is deranged, the damage is usually permanent since the vestibular labyrinth does not regenerate once it is partially on fully damaged. This of course does not mean that a person with a deranged labyrinth will remain unstable throughout life. Nature has a very efficient system, technically known as vestibular compensatory mechanism by virtue of which the balance function of the body is brought back to normal inspite of a damaged labyrinth. This vestibular compensatory mechanism is nature's way of treating peripheral vestibular disorders and ameliorating the patient's symptoms. However, the vestibular compensatory mechanism is inhibited by drugs, which sedate the central nervous system, and by lack of vestibular stimuli. The more the vestibular stimuli like head movements, walking etc. the better does this compensatory mechanism develops. Hence, as soon as the acute symptoms of dizziness pass off, the patient should be encouraged to start his normal physical activities such that the vestibular compensatory mechanism develops properly. Neurotologists hence encourage patients of peripheral vestibular disorders to start physical exercises and resume normal activities as early as possible. Staying in a dark room (lack of visual stimuli) or lying down in bed (lack of proprioceptive stimuli) or immobility (lack of labyrinthine stimuli) jeopardizes the proper development of the vestibular compensatory mechanism. Hence, normal physical activity and exercises are a very important part of therapy in balance disorder patients and the clinician should never undermine its role in hastening early recovery. The importance of physical therapy in the management of vertigo has been widely accepted by neurotologists as the most cost-effective way of treating peripheral vestibular disorders. More and more patients are getting better and returning to normal lives by virtue of this form of treatment. Physical therapy for vertigo, technically known as vestibular rehabilitation exercises, are a form of coordinated head, body and eye movements which help to ameliorate the patient's symptoms and help the vertiginous patient to return to normal life early. The excersises are depicted below(Please Click Here). The vestibular rehabilitation exercises act in 3 ways in the process in peripheral vestibular disorders. These 3 mechanisms are viz.- Adaptation, Habituation, and Compensation. Adaptation is the process by which the brain learns to adapt itself to the changed vestibular scenario, i.e. improper signals coming from the impaired peripheral sensory receptors. The function of the vestibulo-ocular reflex system is to stabilize the image of the surroundings in the retina and keep it at its most sensitive point- the fovea. In derangement of the visual / labyrinthine inputs, this mechanism is jeopardized. The gaze stabilization exercises in this exercise schedule helps to adapt and retrain the vestibular reflex system so that it can effectively bring about the stabilation of images in the retina and avoid the unwanted retinal-slip in spite of there being a defect in the visual / labyrinth inputs. Retinal slip means slippage of images in the retina and is one of the major causes of vertigo, which occurs because of a defective vestibulo-ocular reflex system. Habituation is the process by which the vertiginous patient is repeatedly exposed to the mismatched sensory input. This repetitive exposure to the "error" situation induces changes in the brain such that the brain becomes conditioned to the mismatched sensory input. The head and body movement exercises in the vestibular rehabilitation exercises help to enhance habituation. Compensation means the proper and fullest utilization of the remaining sensory components viz.- the visual and proprioceptive senses and the unaffected labyrinth such that improper input coming from the defective labyrinth is overruled. In a normal subject there is redundancy of the sensory inputs and the fullest utilization of all the 3 inputs system is usually not required. But when one of these input systems is partially or wholly defective the brain is forced to use remaining senses more effectively and efficiently such that they compensate for the partial loss of function. The patient of peripheral vestibular disorder has to understand that one of the objectives of the vestibular rehabilitation exercises is to deliberately and systematically provoke tolerable spells of vertigo so that the threshold of tolerance is elevated. Hence some spells of vertigo in the initial stages may occur during the exercises but it is bound to pass off with time. Diligence regularity and perseverance on the part of the patient is essential such that the desired results can be obtained. The exercises should be performed for 10-15 minutes twice or thrice daily till the subject becomes completely normal. However, even after the patient becomes normal there may be small phases of vertigo during period of fatigue, stress and strain, illness, long periods of inactivity etc. This phenomenon is called decompensation and occurs because the central compensatory mechanism is rather fragile. Whenever such conditions recur the vestibular rehabilitation exercises must be started afresh. In those refractory cases of vertigo, which are not amenable to physical and medical therapy, the neurotologist has to take recourse to surgery. However, the role of surgery in vertigo is very limited. Other than in conditions like acoustic neuroma ( a tumor in the vestibular nerve) or the tumors / abscesses in the cerebellum or in vascular loops ( where a loop of blood vessel presses upon and stimulates the vestibulars of nerve), the scope of surgery is limited. The scope of surgery in peripheral vestibular disorders is only in some stubborn cases of confirmed Meniere's disease, some cases of benign positional vertigo, which is not responding to exercises and in conditions like perilymph fistula and labyrinthitis due to otitis media. In perilymph fistula the fistula is repaired and in labyrinthitis due to otitis media a mastoidectomy is done. These are relatively very simple surgical procedures. But the surgery for Meniere's disease and for benign positional vertigo is difficult and hazardous - the main problem being loss of hearing. Now-a-days some simpler surgical procedures are tried in Meniere's disease like instillation of some chemical toxins like - gentamycin in the middle ear. The results of such procedures are quite encouraging provided of course the patients are properly selected. However, one should remember that surgery in peripheral vestibular lesions whether it be selective vestibular neurectomy or sectioning of the 8th Cr. Nerve or destruction of the vestibular labyrinths or even the procedures like intratympanic gentamycin does not itself relieve the patient's symptoms. The patient's symptoms are relieved only by the vestibular compensation which follows when the offending vest. Labyrinth is totally damaged. The purpose of surgery is to convert a partially damaged unstable labyrinth into a totally dead labyrinth so that the comentsatory mechanism develops properly.

Bananas 'may be key to fight Aids'

In laboratory tests, scientists found that a banana ingredient called BanLec was as potent as two existing anti-HIV drugs.


They believe cheap therapies based on BanLec have the potential to save millions of lives.

The ingredient is a lectin, a naturally occurring chemical in plants which fights infection.

Researchers in the US found that the lectin found in bananas can inhibit HIV infection by blocking the virus's entry into the body. BanLec acts on the protein "envelope" that encloses HIV's genetic material.

Lead author Michael Swanson, from the University of Michigan, said: "The problem with some HIV drugs is that the virus can mutate and become resistant, but that's much harder to do in the presence of lectins.

"Lectins can bind to the sugars found on different spots of the HIV-1 envelope, and presumably it will take multiple mutations for the virus to get around them."

The research is reported in the Journal of Biological Chemistry.

Wednesday, September 8, 2010

Saw palmetto

Saw palmetto ( Serenoa repens ,  Sabal serrulata ) is used popularly in Europe for symptoms associated with benign prostatic hypertrophy (enlargement of the prostate). Although not considered standard of care in the United States, it is the most popular herbal treatment for this condition.

Saw palmetto was listed in the United States Pharmacopeia from 1906 to 1917 and in the National Formulary from 1926 to 1950. Saw palmetto extract is a licensed product in several European countries.
Multiple mechanisms of action have been proposed, and saw palmetto appears to possess 5-α-reductase inhibitory activity (thereby preventing the conversion of testosterone to dihydrotestosterone). Hormonal/estrogenic effects have also been reported, as well as direct inhibitory effects on androgen receptors and anti-inflammatory properties.
In theory, PSA (prostate specific antigen) levels may be artificially lowered by saw palmetto, based on a proposed mechanism of action of saw palmetto (inhibition of 5-α-reductase). Therefore, there may be a delay in diagnosis of prostate cancer or interference with following PSA levels during treatment or monitoring in men with known prostate cancer.

Monday, September 6, 2010

New trials show acetaminophen better than placebo for OA

OA Treatment -View an interactive Webcast reviewing the spectrum of current treatment options for OA of the knee, as well as patient case studies.



Jul 20, 2004

Sutton-in-Ashfield, UK - Acetaminophen (paracetamol) is more effective than placebo in relieving the pain of large joint osteoarthritis (OA), according to a Leader in the August 2004 issue of the Annals of the Rheumatic Diseases [1]. But NSAIDs and coxibs are superior to acetaminophen, it adds.

Three new papers on acetaminophen and OA accompany this Leader, an unprecedented occurrence. "Never in the 127 years history of acetaminophen's existence have so much trial data on OA been reported,"

The new papers consist of a meta-analysis and 2 large-placebo-controlled studies of the efficacy of acetaminophen in OA.





Meta-analysis: acetaminophen should remain first-line therapy

Although current EULAR and ACR guidelines both support acetaminophen as the first-line oral analgesic for patients with knee OA, "until now there has been a paucity of clinical trial data to confirm the efficacy of paracetamol in large joint OA," Neame et al say in their Leader.

Until now there has been a paucity of clinical trial data to confirm the efficacy of paracetamol in large joint OA.

There have been only 4 placebo-controlled trials of this drug in OA, they note. The first 2 showed the superiority of acetaminophen over placebo, but they were small. A third, slightly larger, study was negative, however, while a fourth crossover study showed that acetaminophen was effective for pain but was no better than placebo for total WOMAC scores.

In the light of these heterogeneous data, Dr Weiya Zhang (University of Nottingham, UK) et al have undertaken a new meta-analysis of evidence available to July 2003 [2].

This included 10 randomized controlled trials and shows that acetaminophen gives pain relief in OA that is better than placebo (effect size 0.21; 95% CI 0.02-0.41).

However, NSAIDs were better than acetaminophen for pain relief, and clinical response rate was higher with NSAIDS than with acetaminophen. Also, the number of patients who preferred NSAIDs was more than twice the number preferring acetaminophen.

Professor Michael Doherty (University of Nottingham, UK)—an author of the Leader and the meta-analysis—told rheumawire that "despite the findings that NSAIDs are more efficacious than paracetamol, the latter should remain first-line therapy for knee OA."

[Paracetamol] should remain first-line therapy for knee OA.

The safety record of acetaminophen at the recommended dosage "is excellent," and "it is very cheap and widely available," he says. Only if acetaminophen proves insufficient should NSAIDs be considered, he believes, because they "can kill you!"

"Most patients with OA are old or elderly and are at increased risk of NSAID-associated peptic ulceration/bleeding/perforation. If they are given NSAIDs they should be considered for prophylaxis (combined proton pump inhibitors [PPIs] or misoprostol) or be given a coxib,"